Partial Coefficient Calculator

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Partial Coefficient Calculator:

Enter the values of concentration of solute in solvent 1, C1(mol/L)and concentration of solute in solvent 2, C2(mol/L)to determine the value of Partition Coefficient, Kp.

Enter Concentration of Solute in Solvent 1 : mol/L
Enter Concentration of Solute in Solvent 2 : mol/L
   
Result – Partition Coefficient :

Partial Coefficient:

The partition coefficient (Kp) is a ratio that describes how a solute distributes itself between two immiscible solvents at equilibrium.It is typically used in chemistry, pharmacology, and environmental science to predict how substances will behave when placed in different environments.The two solvents involved are usually one polar (like water) and one non-polar (like octanol or ether).

Kp is defined as the concentration of the compound in one solvent divided by its concentration in the other solvent.This coefficient helps determine the solubility preference of a compound between two immiscible phases.A high Kp value indicates the solute prefers the organic (non-polar) phase, while a low Kp value means it favors the aqueous (polar) phase.

Kp is important in drug development because it helps understand how drugs partition in body fluids and tissues.It is also used in environmental studies to predict how pollutants spread between water and soil or air.Kp is dimensionless because it’s a ratio of two concentrations with the same units.For the equilibrium constant Kp to remain applicable, it is assumed that the system has reached equilibrium and that the temperature stays unchanged throughout the process.

The units for concentrations (such as mg/L or mol/L) cancel out in the ratio.Kp depends only on the nature of the solute and the solvents and is not influenced by the amount of each solvent used.Experimentally, Kp can be determined by shaking the solute with both solvents, letting the layers separate, and analyzing each layer.

It is especially relevant in extractions, chromatographic separations, and assessing toxicity of substances.The partition coefficient reveals whether a compound prefers a water-based (hydrophilic) or fat-based (lipophilic) environment.

Partition Coefficient, Kp equals the concentration of solute in solvent 1, C1(mol/L)in moles per litre divided by the concentration of solute in solvent 2, C2(mol/L)in moles per litre.

Partition Coefficient, Kp = C1(mol/L)/ C2(mol/L)

Kp = partition coefficient.

C1(mol/L)= concentration of solute in solvent 1 in moles per litre, mol/L.

C2(mol/L)= concentration of solute in solvent 2 in moles per litre, mol/L.

Partial Coefficient Calculation:

  1. A solute is dissolved in a two-phase system consisting of chloroform and water. The concentration in chloroform (C1) is 0.80 mol/L, and in water (C2) it is 0.20 mol/L. What is the partition coefficient?

Given: C1(mol/L)= 0.80mol/L, C2(mol/L)= 0.20mol/L.

Partition Coefficient, Kp = C1(mol/L)/ C2(mol/L)

Kp = 0.80 / 0.20

Kp = 4.

  1. The partition coefficient of a substance between benzene and water is 2.5. If the concentration in water (C2) is 0.40 mol/L, what is the concentration in benzene (C1)?

Given: Kp = 2.5, C2(mol/L)= 0.40mol/L.

Partition Coefficient, Kp = C1(mol/L)/ C2(mol/L)

C1(mol/L)= Kp *C2(mol/L)

C1(mol/L)= 2.5 * 0.40

C1(mol/L)= 1.00mol/L.

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